Organic Chemistry 2 (Chem 12B)

Organic Chemistry II covers the structure and reactions of alcohols and ethers, dienes and aromatics, aldehydes and ketones, acids and derivatives, and amines. Nomenclature of organic compounds, stereochemistry, and reaction mechanisms will be discussed.

Course Content, Objectives, Lecture Slides, Lecture Videos, Quiz Practice Problems, Practice Problem Solutions

pKa table (more extensive than pKa table in textbook)

10 Steps of Glycolysis video

Quiz Practice Problems – doing these practice problems and spreading them out over time are really good for active retrieval of information to improve your long term retention. Important: Try answering the questions first before you look at the solutions.

Objective 1: Review CHM 12A substitution, elimination, addition, and acid-base reactions.

Objective 2: Identify and understand an organic oxidation and reduction reactions.

Objective 3: Apply substitution and elimination concepts to ethers and epoxides.

Objective 4: Determine (characterize) the structure of a compound using IR, NMR, MS.

Objective 5: Identify a conjugated diene and understand electrophilic addition reactions of dienes.

Objective 6: Identify an aromatic compound and apply substitution, elimination, and oxidation-reduction principles to aromatic side chain reactions.

Objective 7: Apply addition and elimination concepts to predict electrophilic aromatic substitution reactions (EAS).

Objective 8: Understand electrophilic aromatic substitution reactions (EAS) of substituted aromatics.

Objective 9: Understand nucleophilic addition reactions of O and C nucleophiles to C=O compounds.

Objective 10: Understand nucleophilic addition reactions of N nucleophiles to C=O compounds.

Objective 11: Apply acid-base principles to organic acids.

Objective 12: Apply nucleophilic addition and elimination concepts to nucleophilic acyl substution reactions of acids and derivatives.

Objective 13: Apply nucleophilic addition and elimination concepts to enols and enolates reactions.

Objective 14: Apply acid-base, substitution, and elimination principles to amines.

Objective 15: Develop synthesis strategies for organic synthesis.

Objective 16: Apply organic chemistry lab skills, which include the proper use and operation of organic lab chemicals, equipment, instruments, lab tecniques, and safety procedures, to experiments.

Student Learning Outcomes

By the end of the course, you should be able to apply the course objectives to:

(i) Given the name of an organic compound, relate the physical properties, chemical properties, and uses to the compound’s major functional groups and structure.

(ii) Given reactants, predict products and propose mechanisms for organic reactions.

(iii) Given an organic compound, design a synthesis.

(iv) Given IR, NMR, and mass spectra, deduce the formula and structure of organic compounds.

(v) Demonstrate proficiency in basic laboratory skills used in organic chemistry.